Poison Guide

Note: This page explains the current community debate around Poison. It is not an official tier list.

What is Poison?

Poison is a dice type that deals damage over time (DOT). It is passive damage that does not need immediate burst rolls to stay relevant.

That makes Poison attractive in longer fights, because damage can keep building while you focus on surviving and maintaining the run. The tradeoff is that Poison can feel slow when enemies need to die quickly.

Community Debate

There has been significant community discussion about Poison, and the latest April 24-26 wave is noticeably more positive than the earlier “Poison feels weak” reactions.

Arguments FOR Poison

• “Poison scales hard once backpack dice start counting”
• “High damage in long fights and shield-heavy stages”
• “Acorn Miasma + Does Not Enter Play has real synergy”
• “Poison Pop looks overtuned when it appears”

Arguments AGAINST (or cautious)

• “Ramp-up is slow”
• “Weak against short encounters”
• “Still bad if the run never offers support pieces”

Key Upgrades

Must-Have for Poison

• For Each Dice You Have - One of the biggest community-tested scaling pieces
• Does Not Enter Play - Lets Poison scale off off-board dice
• Acorn Miasma - Commonly cited as the route’s best glue piece
• Poison Pop / enemy-action triggers - Strong payoff when offered

When to Consider Poison

Poison makes more sense when:

• The fight lasts long enough for damage over time to matter
• The stage has shields or enough health that sustained damage matters
• You already see upgrades that support stacking or keeping poison active
• Your current route needs passive damage instead of immediate burst

Be careful if the stage is short, time-sensitive, or built around enemies that need fast burst damage. In those cases, Poison may underperform even if it looks strong on paper.

Verdict

Community consensus:

• Poison is currently one of the more promising long-fight routes
• It looks especially strong when backpack-dice synergies show up
• It is still not ideal for short burst encounters
• It works best with specific support pieces rather than as a blind default

Disclaimer: This is community experience, not verified fact. Game balance changes may affect viability.